How quickly does calcium drop after parathyroidectomy

Problems affecting the parathyroid glands can cause an imbalance of calcium and require removal of one or more of the glands. Traditional parathyroidectomy involves a small incision in the front of the neck; however, newer transoral (through the mouth) procedures leave no visible scar and may be an option.

What You Need to Know

  • The four parathyroid glands, each about the size of a grain of rice, are located behind the thyroid gland in the neck.
  • Hormones from the parathyroid glands regulate blood levels of calcium and other minerals. Parathyroid gland problems requiring parathyroidectomy include hyperparathyroidism, parathyroid nodules and parathyroid tumors.
  • Surgeons can access the parathyroid glands through an incision at the front of the neck, or through the mouth (scarless procedure). 

 Why might I need a parathyroidectomy?

The parathyroid glands can develop benign (or, rarely, malignant) growths that cause over- or under-production of parathyroid hormone (PTH). Radiation therapy, nutritional deficiencies and the use of some medications such as lithium can also damage the parathyroid glands and affect their production of PTH.

An imbalance of PTH affects blood levels of calcium. Too little calcium can cause bone problems, depression, fatigue and other symptoms, while too much calcium can result in problems such as kidney stones, muscle spasms and nerve pain.

Blood tests, urinalysis, bone density screenings and imaging tests can help the doctor determine if there is a problem with your parathyroid glands that requires removal.

What are the risks of parathyroidectomy?

  • Persistent low blood calcium levels

  • Voice changes, such as hoarseness

  • Sore throat

  • Bleeding and blood clots

  • Adhesions or scar tissue requiring further surgery

  • Injury to the esophagus or trachea (windpipe)

What happens during a parathyroidectomy?

Before the Procedure

The doctor may order imaging and laboratory tests, such as:

  • Ultrasound, sestamibi nuclear medicine scan, computed tomography (CT) or magnetic resonance imaging (MRI) to visualize the parathyroid glands and surrounding areas

  • Blood test(s), urinalysis, bone density screening

  • Examination of the vocal cords and their function using an instrument called a laryngoscope

Just before your procedure, the surgical team may give you an antibiotic if you are prone to infections because of a problem with your immune system or other condition. You may receive medicines to reduce nausea and vomiting (antiemetics).

Different Types of Parathyroidectomy

Traditional Parathyroidectomy

Most parathyroidectomies take place while the person is under general anesthesia, asleep and pain-free.

The surgeon makes a small incision in the skin of the neck and parts a thin layer of muscle to gain access to the thyroid gland and the parathyroid glands behind it. The surgeon can examine the parathyroid glands and remove those that are damaged or affected by disease.

The surgeon then returns the muscles of the front of the neck to their proper position and secures them in place. The skin is closed with sutures or glue.

Neck Surgery’s Scarless Alternative

When Gwen met with head and neck endocrine surgeon Jonathon Russell, M.D. , at Johns Hopkins to discuss a thyroidectomy, she mentioned symptoms such as low bone density, fatigue and kidney stones. Russell diagnosed Gwen with hyperparathyroidism caused by a parathyroid nodule.

Scarless (Transoral) Parathyroidectomy

This is a newer technique for select patients that involves accessing the parathyroid glands through the mouth. This surgery leaves no visible scar since there is no incision on the outside of the neck.

Parathyroidectomy: Recovery and Next Steps

After a parathyroidectomy, you are likely to go home with some calcium supplements until the remaining normal parathyroid glands “wake up” and resume functioning.

Voice

Your voice is generally not affected because in most cases local anesthesia is used, and a breathing tube is not necessary.

Activity

Your activity level depends on the amount of discomfort you have. You can resume sports activities 2 weeks after surgery. Most patients are able to return to work in the first week. You are able to drive as soon as your head can be turned comfortably.

Low Calcium Levels After Surgery

In all patients who have parathyroid surgery, the remaining parathyroid glands that have not been doing any work, do not function properly immediately after surgery. This is usually temporary and causes the blood calcium level to drop below normal (this is called hypocalcemia).

Symptoms of Hypocalcemia

  • Numbness and tingling in your hands, soles of your feet and around your lips
  • Some patients experience a “crawling” sensation in the skin
  • Muscle cramps
  • Severe headaches

These symptoms appear between 24 and 48 hours after surgery. It is rare for them to start after 72 hours.

Hypocalcemia Prevention

Prior to the surgery we will give you specific instructions (table below) as to how much calcium and vitamin D replacement you will need to take after surgery. This is dependent on your pre-surgery calcium levels and the number of glands that are diseased.

How quickly does calcium drop after parathyroidectomy

Hypocalcemia Symptom Treatment

Patients with calciums of less than 14 prior to surgery: at any point if symptoms develop, you should take 8 extra Citracal Petites pills and call Dr. Larian ASAP.

Patients with calciums more than 14 prior to surgery, or with hyperplasia: if symptoms develop, you should take an extra 2000 milligrams of Calcium, and an extra Rocalcitrol, and call Dr. Larian ASAP.

After Surgery Blood Tests

(You will be given prescriptions for these tests)

  • One month after surgery: Calcium, PTH & Vitamin D Levels.

Bleeding

If bleeding occurs, you will notice immediate swelling in the neck and difficulty breathing. This is extremely rare but it is an absolute emergency. If it does occur, CALL 911 immediately.

If you would like to know more about post-surgery healing, schedule a consultation with our surgeon or give us a call at 310.461.0300 today!

PARATHYROID TREATMENTS

How long does it take calcium to normalize after parathyroidectomy?

Conclusion: The majority of patients with primary hyperparathyroidism (PHP) respond to parathyroidectomy in the form of normalization of their serum calcium levels and PTH within 48 h; however, a certain group of patients will need more than 3 days.

How long does it take for PTH to normalize after parathyroidectomy?

Among the 13 patients with normalization of their PTH levels, 8 had more rigorous follow-up and were shown to experience normalization of PTH levels within 1 to 5 months following parathyroidectomy.

How long does it take for calcium levels to return to normal?

The serum calcium level will start to decrease within 2 to 4 hours and approach the normal range in 12 to 24 hours.

How soon do symptoms go away after parathyroid surgery?

Conclusions. Symptom improvement was most prominent 6 weeks post-parathyroidectomy, though some symptoms showed continued improvement at 6 months.