Mutation is the original source of genetic variation

Review

Mutation as an origin of genetic variability in Helicobacter pylori

G Wang et al. Trends Microbiol. 1999 Dec.

Abstract

The availability of two complete Helicobacter pylori genome sequences and recent studies of its population genetics have provided a detailed picture of genetic diversity in this important human gastric pathogen. It is believed that, in addition to genetic recombination, de novo mutation could have a role in generating the high level of genetic variation in H. pylori.

Comment in

  • Sequence variation in Helicobacter pylori.

    Achtman M, Suerbaum S. Achtman M, et al. Trends Microbiol. 2000 Feb;8(2):57-8. doi: 10.1016/s0966-842x(99)01676-5. Trends Microbiol. 2000. PMID: 10664596 No abstract available.

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MeSH terms

Are mutations the source of genetic variation?

Genetic variations can arise from gene variants (also called mutations) or from a normal process in which genetic material is rearranged as a cell is getting ready to divide (known as genetic recombination). Genetic variations that alter gene activity or protein function can introduce different traits in an organism.

What is the origin of the variation?

This view of evolution held that variation in populations was the result of random genetic mutation and recombination, and as a result, proposed that populations evolve by changes in gene frequencies due to genetic drift, gene flow, and natural selection.

What are mutations the source of?

In general, mutation is the main source of genetic variation, which is the raw material for evolution by natural selection.

What are the 3 origins of genetic variation?

The genetic diversity has three different sources: mutation, recombination and immigration of genes. Mutation is the driving force of genetic variation and evolution.